Statins In The Musculoskeletal Landscape

An Evidence Based Inquiry

What you'll learn
1. Increase awareness and recognition of statin intolerance in musculoskeletal patients.
2. Learn the risk factors associated with Statin Associated Muscle Symptoms (SAMS).
3. Identify the signs and symptoms of myositis/myopathy.
4. Understand the physiological process involved with SAMS and tests to confirm.

Requirements
Must be a medical professional.
Ideal for the musculoskeletal professional such as Physical Therapists and Assistants, Occupational Therapsids and Assistants, Doctors of Chiropractic, Physicians, Athletic Trainers, Massage Therapists

Description
This is a one-hour heavily evidence-based inquiry designed for musculoskeletal clinicians on statin intolerance and SAMS or statin-associated muscle symptoms. Statin intolerance may affect certain individuals who are on statins with muscle pain and spasm. I was not aware of this issue until I had a patient four years ago with the strangest bilateral lower extremity muscle pain that eventually resolved when she went off the statin. I started researching the topic and was fascinated by the information and felt I needed to share it. Hence the development of this course.Statin intolerance may affect up to 9% of statin users. It is a very controversial subject. Some researchers and physicians say muscle symptoms are due to the nocebo effect and the beliefs of the patient that the drug is doing them harm and other researchers and physicians feel SAMS is a valid issue and the prevalence of SAMS is upwards of 20% of statin users. Even the Mayo Clinic has a statin intolerance clinic.This evidence-based inquiry course comprehensively explores statin muscle pain and intolerance for musculoskeletal healthcare professionals. It covers a wide range of topics, including symptoms, risk factors, types of statins, potential mechanisms, research findings, diagnostic tools, and effective management strategies. Additionally, the course delves into the controversies surrounding statin therapy, as well as the potential benefits and risks associated with the use of these medications.This course is not designed to tell your patients to stop taking statins It is designed to give you information to screen your patients and refer them to their physician or cardiologist for further investigation.This course is designed for medical professionals and not the general public.Course Outline:I. Introduction to Statin Muscle Pain and Intolerance a. Definition and prevalence of statin muscle pain and intolerance b. FDA information for clinicians and patients c. Importance of statinsd. Benefits and risks of statin therapy2. Statin Overview of the symptoms and risk factors of statin muscle pain and intolerance a. Symptoms and possible side effects b. Risk factors3. Types of Statins a. Lipophilic b. Hydrophilicc. Dosage discussion4. Diagnosis of Statin Muscle Pain and Intolerance a. Creatine Kinase b. Diagnostic tools c. Statin-associated muscle symptom clinic index d. Mayo Clinic Statin Intolerance Service5. Nocebo Effect a. Discussion of the nocebo effect b. Ways to prevent the nocebo effect6. Position paper international lipid expert panel a. Paper findings and outcomes7. Research a. SAMS and low incidence reasons in research b. STOMP Study (2013) c. Lancet Report (2022) d. Meta-analysis Davis et al (2021) e. Meta-analysis prevalence of statin intolerance Bytuci I et al (2022)8. Mechanism behind SAMS9. Levels of Muscle Involvement a. Rhabdomyolysis b. Myalgia and Mild HyperCKemia c. Self-Limited Toxic Statin Myopathy d. Statin Associated Autoimmune Necrotizing Myopathy10. Differential Diagnosis of Muscle Pain a. Immune-mediated myopathies b. Other possible diagnoses11. Statins and Tendinopathy12. Drug and Food Interaction13. Statins in Rehabilitation14. Case study of a patient with statin muscle pain and intolerance15. Summary and Conclusions a. Summary of key concepts covered in the course b. Quiz c. References

Overview
Section 1: Introduction

Lecture 1 Introduction

Lecture 2 Course Outline

Lecture 3 Disclaimer

Section 2: Details

Lecture 4 Definition of Statin Intolerance

Lecture 5 Importance of statins

Lecture 6 Symptoms of SAMS and RIsk Factors

Lecture 7 Types of Statins and Dosage

Lecture 8 Testing and Diagnosis of Statin Muscle Pain and Intolerance

Lecture 9 Nocebo Effect

Lecture 10 Position Paper International Lipid Expert Panel

Lecture 11 Research

Lecture 12 Mechanism Behind SAMS

Lecture 13 Levels of Muscle Involvement

Lecture 14 Drug and Food Interaction

Lecture 15 Statins in Rehabilitation

Lecture 16 Case Study of a Patient with Statin Muscle Pain and Intolerance

Lecture 17 Summary and Conclusions

Lecture 18 Thank You

Section 3: References

Lecture 19 References

Lecture 20 Bonus Lecture and Coupons

Musculoskeletal medical professionals,Ideal for the musculoskeletal professional such as Physical Therapists and Assistants, Occupational Therapsids and Assistants, Doctors of Chiropractic, Physicians, Athletic Trainers, Massage Therapists. This is an entry level course

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