Purinergic System

This book describes the purinergic system and its correlation with the health and disease process.

Characterized as a common signaling pathway between cells, the purinergic system is capable of modulating physiological and biochemical processes. Composed of signaling molecules, regulatory enzymes, and specific receptors, this organization can modulate several basal pathways of the organism. It is understood that purinergic signaling is present in all aspects of immunity and inflammation and studies show that extracellular ATP and its adenosine metabolite are the main mediators of response. These occur since most immune cells express P2 and P1 receptors, which are sensitive to the ATP and adenosine molecules, respectively.

Contents
1. Purinergic System in Immune Response
2. Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases
3. Purinergic Signaling in Covid-19 Disease
4. Graft-Versus-Host Disease: Pathogenesis and Treatment
5. Involvement of the Purinergic System in Cell Death in Models of Retinopathies
6. Leukaemia: The Purinergic System and Small Extracellular Vesicles
7. Immunomodulatory Effects of a M2-Conditioned Medium (PRS® CK STORM): Theory on the Possible Complex Mechanism of Action through Anti-Inflammatory Modulation of the TLR System and the Purinergic System
8. The Potential of the Purinergic System as a Therapeutic Target of Natural Compounds in Cutaneous Melanoma